Abstract
We experienced the first death case of the serotonin syndrome in Japan caused by fluvoxamine and tandospirone. A 15-year-old man was transported to our hospital for shock, muscle hypertonia and hyperthermia after cardiopulmonary arrest. His serum concentrations of fluvoxamine and tandospirone were 3,554 ng/mL and 698 ng/mL respectively after 24 hours from oral intake. He was dead in spite of intensive treatments. The progress of the serotonin syndrome is usually rapid. So, it should be monitored appropriately a patient with serotonin syndrome. If he has hyperthermia, immediate paralysis should be induced. We should aware of the serotonin syndrome a case of overdose on a serotonergic agent.
Publication types
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Case Reports
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English Abstract
MeSH terms
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Adolescent
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Anti-Anxiety Agents / adverse effects*
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Anti-Anxiety Agents / blood
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Drug Overdose
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Fatal Outcome
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Fever / chemically induced*
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Fluvoxamine / adverse effects*
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Fluvoxamine / blood
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Heart Arrest / chemically induced
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Humans
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Isoindoles / adverse effects*
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Isoindoles / blood
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Japan
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Male
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Muscle Hypertonia / chemically induced*
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Piperazines / adverse effects*
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Piperazines / blood
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Pyrimidines / adverse effects*
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Pyrimidines / blood
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Selective Serotonin Reuptake Inhibitors / adverse effects*
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Selective Serotonin Reuptake Inhibitors / blood
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Serotonin Receptor Agonists / adverse effects*
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Serotonin Receptor Agonists / blood
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Severity of Illness Index
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Shock / chemically induced
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Syndrome
Substances
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Anti-Anxiety Agents
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Isoindoles
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Piperazines
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Pyrimidines
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Serotonin Receptor Agonists
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Serotonin Uptake Inhibitors
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tandospirone
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Fluvoxamine