Celecoxib pathways: pharmacokinetics and pharmacodynamics

Pharmacogenet Genomics. 2012 Apr;22(4):310-8. doi: 10.1097/FPC.0b013e32834f94cb.
No abstract available

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics*
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Aryl Hydrocarbon Hydroxylases / genetics
  • Biomarkers, Pharmacological*
  • Cardiovascular Abnormalities / chemically induced
  • Celecoxib
  • Cyclooxygenase 1 / genetics
  • Cyclooxygenase 1 / metabolism
  • Cyclooxygenase 2 / genetics
  • Cyclooxygenase 2 / metabolism
  • Cyclooxygenase 2 Inhibitors / adverse effects
  • Cyclooxygenase 2 Inhibitors / pharmacokinetics*
  • Cyclooxygenase 2 Inhibitors / therapeutic use
  • Cytochrome P-450 CYP2C9
  • Genetic Association Studies
  • Humans
  • Inflammation / drug therapy*
  • Metabolic Networks and Pathways / genetics
  • Pyrazoles / adverse effects
  • Pyrazoles / pharmacokinetics*
  • Pyrazoles / therapeutic use
  • Sulfonamides / adverse effects
  • Sulfonamides / pharmacokinetics*
  • Sulfonamides / therapeutic use
  • Treatment Outcome

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Biomarkers, Pharmacological
  • Cyclooxygenase 2 Inhibitors
  • Pyrazoles
  • Sulfonamides
  • CYP2C9 protein, human
  • Cytochrome P-450 CYP2C9
  • Aryl Hydrocarbon Hydroxylases
  • Cyclooxygenase 1
  • Cyclooxygenase 2
  • PTGS1 protein, human
  • PTGS2 protein, human
  • Celecoxib