Adhesion molecules in cancer of the head and neck: role of dysadherin

I Giotakis; A Chrysovergis; A Georgolios; E Giotakis; L Manolopoulos

Adhesion molecules in cancer of the head and neck: role of dysadherin

J BUON. 2011 Oct-Dec;16(4):609-12.

Authors

I Giotakis¹, A Chrysovergis, A Georgolios, E Giotakis, L Manolopoulos

Affiliation

¹ ENT Department, University of Athens, Hippokrateion Hospital, Athens, Greece.

PMID: 22331710

Abstract

Dysadherin is a recently discovered cancer-related cell membrane glycoprotein that has an important role in tumor progression and metastasis. We are focusing on the role of dysadherin in E-cadherin downregulation, the different expression patterns of the molecule in cancer of the head and neck and its potential role as a molecular target for future applications in diagnosis, prognosis, and management of the disease.

Publication types

Review

MeSH terms

Cadherins / biosynthesis
Cadherins / metabolism*
Carcinoma, Squamous Cell / metabolism*
Carcinoma, Squamous Cell / pathology
Cell Adhesion / physiology
Cell Adhesion Molecules / metabolism*
Female
Head and Neck Neoplasms / metabolism*
Head and Neck Neoplasms / pathology
Humans
Ion Channels
Male
Membrane Glycoproteins / metabolism*
Microfilament Proteins
Neoplasm Proteins / metabolism*

Substances

Cadherins
Cell Adhesion Molecules
FXYD5 protein, human
Ion Channels
Membrane Glycoproteins
Microfilament Proteins
Neoplasm Proteins