Toward deciphering proteomes of formalin-fixed paraffin-embedded (FFPE) tissues

Proteomics. 2012 Apr;12(7):1045-58. doi: 10.1002/pmic.201100550.

Abstract

Formalin-fixed paraffin-embedded (FFPE) tissue specimens comprise a potentially valuable resource for both prospective and retrospective biomarker discovery. Unlocking the proteomic profile of clinicopathological FFPE tissues is a critically essential step for annotating clinical findings and predicting biomarkers for ultimate disease prognosis and therapeutic follow-up.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acids / analysis
  • Animals
  • Formaldehyde*
  • Humans
  • Mice
  • Paraffin Embedding*
  • Protein Stability
  • Proteome / analysis*
  • Proteome / chemistry*
  • Proteomics / methods*
  • Proteomics / standards
  • Reproducibility of Results
  • Solvents / chemistry

Substances

  • Amino Acids
  • Proteome
  • Solvents
  • Formaldehyde