Occurrence of spontaneous resolution of ketoprofen with a racemic crystal structure by simple crystallization under nonequilibrium preferential enrichment conditions

Rajesh G Gonnade; Sekai Iwama; Ryusuke Sugiwake; Kochunnoonny Manoj; Hiroki Takahashi; Hirohito Tsue; Rui Tamura

doi:10.1039/c2cc18132k

Occurrence of spontaneous resolution of ketoprofen with a racemic crystal structure by simple crystallization under nonequilibrium preferential enrichment conditions

Chem Commun (Camb). 2012 Mar 14;48(22):2791-3. doi: 10.1039/c2cc18132k. Epub 2012 Feb 7.

Authors

Rajesh G Gonnade¹, Sekai Iwama, Ryusuke Sugiwake, Kochunnoonny Manoj, Hiroki Takahashi, Hirohito Tsue, Rui Tamura

Affiliation

¹ Graduate School of Human and Environmental Studies, Kyoto University, Kyoto 606-8501, Japan.

PMID: 22315146
DOI: 10.1039/c2cc18132k

Abstract

Nearly racemic ketoprofen, which satisfies the requirements for the occurrence of preferential enrichment, was spontaneously resolved into the two enantiomers by simple crystallization under nonequilibrium conditions using high concentrations.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Crystallography, X-Ray
Ketoprofen / chemistry*
Models, Molecular
Molecular Conformation
Stereoisomerism

Substances

Ketoprofen