Effects of a lactobacilli, oligosaccharide and organic germanium intake on the immune responses of mice

Biosci Biotechnol Biochem. 2012;76(2):375-7. doi: 10.1271/bbb.110655. Epub 2012 Feb 7.

Abstract

The organic germanium compound, Ge-132, has immune-modulating effects. We evaluated the symbiotic effects of Ge-132 with lactobacilli and oligosaccharide (LB/OS) on the immune responses of mice. The highest fecal IgA levels were observed in the mice receiving a low concentration of Ge-132 with LB/OS for 8 weeks. Our data suggest that LB/OS with a low concentration of Ge-132 stimulated the intestinal immunity.

MeSH terms

  • Animals
  • Drug Synergism
  • Germanium / immunology*
  • Germanium / pharmacology
  • Immunity / drug effects*
  • Immunoglobulin A / analysis
  • Immunomodulation*
  • Interferon Inducers
  • Intestines / immunology
  • Lactobacillus / immunology*
  • Mice
  • Oligosaccharides / immunology*
  • Oligosaccharides / pharmacology
  • Organometallic Compounds / immunology*
  • Organometallic Compounds / pharmacology
  • Propionates

Substances

  • Immunoglobulin A
  • Interferon Inducers
  • Oligosaccharides
  • Organometallic Compounds
  • Propionates
  • Germanium
  • propagermanium