LUBAC, a novel ubiquitin ligase for linear ubiquitination, is crucial for inflammation and immune responses

Fuminori Tokunaga; Kazuhiro Iwai

doi:10.1016/j.micinf.2012.01.011

LUBAC, a novel ubiquitin ligase for linear ubiquitination, is crucial for inflammation and immune responses

Microbes Infect. 2012 Jul;14(7-8):563-72. doi: 10.1016/j.micinf.2012.01.011. Epub 2012 Jan 25.

Authors

Fuminori Tokunaga¹, Kazuhiro Iwai

Affiliation

¹ Laboratory of Molecular Cell Biology, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma 371-8512, Japan.

PMID: 22309894
DOI: 10.1016/j.micinf.2012.01.011

Abstract

LUBAC (linear ubiquitin chain assembly complex) is a ubiquitin ligase complex composed of SHARPIN, HOIL-IL and HOIP that generates linear polyubiquitin chains and regulates the NF-κB pathway, which is pivotal in inflammatory and immune responses. Recent findings on the regulation of NF-κB by LUBAC and the diseases associated with this process are the focus of this review.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Adaptive Immunity / physiology*
Animals
Carrier Proteins / immunology*
Humans
Inflammation / enzymology*
Inflammation / immunology*
Intracellular Signaling Peptides and Proteins
Mice
NF-kappa B / immunology*
Ubiquitin-Protein Ligases / immunology*
Ubiquitination

Substances

Carrier Proteins
HOIL-1L protein, mouse
Intracellular Signaling Peptides and Proteins
NF-kappa B
Sipl1 protein, mouse
Rnf31 protein, mouse
Ubiquitin-Protein Ligases