Oseltamivir-resistant pandemic (H1N1) 2009 virus infections, United States, 2010-11

Emerg Infect Dis. 2012 Feb;18(2):308-11. doi: 10.3201/eid1802.111466.

Abstract

During October 2010-July 2011, 1.0% of pandemic (H1N1) 2009 viruses in the United States were oseltamivir resistant, compared with 0.5% during the 2009-10 influenza season. Of resistant viruses from 2010-11 and 2009-10, 26% and 89%, respectively, were from persons exposed to oseltamivir before specimen collection. Findings suggest limited community transmission of oseltamivir-resistant virus.

MeSH terms

  • Adult
  • Antiviral Agents / pharmacology
  • Antiviral Agents / therapeutic use*
  • Drug Resistance, Viral*
  • Female
  • Humans
  • Influenza A Virus, H1N1 Subtype / drug effects*
  • Influenza A Virus, H1N1 Subtype / isolation & purification
  • Influenza, Human / drug therapy
  • Influenza, Human / epidemiology*
  • Influenza, Human / mortality
  • Influenza, Human / virology
  • Male
  • Oseltamivir / pharmacology
  • Oseltamivir / therapeutic use*
  • Pandemics*
  • Prevalence
  • United States / epidemiology

Substances

  • Antiviral Agents
  • Oseltamivir