Unusual presentations of pediatric neurobrucellosis

Am J Trop Med Hyg. 2012 Feb;86(2):258-60. doi: 10.4269/ajtmh.2012.11-0468.

Abstract

Neurobrucellosis is an uncommon complication of pediatric brucellosis. Acute meningitis and encephalitis are the most common clinical manifestations, however symptoms may be protean and diagnosis requires a high index of suspicion in patients from endemic areas. Diagnosis is often based on neurological symptoms, serology, and suggestive brain imaging because cerebrospinal fluid culture yields are low. Two cases of pediatric neurobrucellosis with unusual clinical and radiologic findings are presented.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Anti-Bacterial Agents / therapeutic use
  • Brucellosis / diagnosis*
  • Brucellosis / drug therapy*
  • Brucellosis / epidemiology*
  • Child
  • Doxycycline / therapeutic use
  • Drug Therapy, Combination / methods
  • Encephalitis / complications
  • Encephalitis / diagnosis
  • Encephalitis / drug therapy
  • Female
  • Gentamicins
  • Humans
  • Incidence
  • Israel
  • Meningitis / complications
  • Meningitis / diagnosis
  • Meningitis / drug therapy
  • Neuroimaging / methods
  • Rifampin / therapeutic use
  • Treatment Outcome
  • Trimethoprim, Sulfamethoxazole Drug Combination / therapeutic use

Substances

  • Anti-Bacterial Agents
  • Gentamicins
  • Trimethoprim, Sulfamethoxazole Drug Combination
  • Doxycycline
  • Rifampin