Abstract
Pulmonary arterial hypertension (PAH) is a debilitating and often fatal disease characterized by a progressive increase in pulmonary vascular resistance that leads to right ventricular failure. Described in this unit is an in vivo model of monocrotaline-induced pulmonary hypertension in rats that can be used to assess the effects of antihypertensive agents on pulmonary artery pressure and right ventricular hypertrophy.
MeSH terms
-
Animals
-
Antihypertensive Agents / pharmacology*
-
Cardiac Output / drug effects
-
Carotid Arteries / surgery
-
Catheterization, Swan-Ganz
-
Disease Models, Animal*
-
Femoral Artery / surgery
-
Femoral Vein / surgery
-
Hypertension, Pulmonary / chemically induced*
-
Hypertension, Pulmonary / drug therapy
-
Hypertension, Pulmonary / physiopathology
-
Hypertrophy, Right Ventricular / drug therapy*
-
Hypertrophy, Right Ventricular / physiopathology
-
Male
-
Monocrotaline*
-
Pulmonary Wedge Pressure / drug effects
-
Rats
-
Rats, Wistar
Substances
-
Antihypertensive Agents
-
Monocrotaline