Stochastic expression of the interferon-β gene

PLoS Biol. 2012 Jan;10(1):e1001249. doi: 10.1371/journal.pbio.1001249. Epub 2012 Jan 24.

Abstract

Virus infection of mammalian cells induces the production of high levels of type I interferons (IFNα and β), cytokines that orchestrate antiviral innate and adaptive immunity. Previous studies have shown that only a fraction of the infected cells produce IFN. However, the mechanisms responsible for this stochastic expression are poorly understood. Here we report an in depth analysis of IFN-expressing and non-expressing mouse cells infected with Sendai virus. Mouse embryonic fibroblasts in which an internal ribosome entry site/yellow fluorescent protein gene was inserted downstream from the endogenous IFNβ gene were used to distinguish between the two cell types, and they were isolated from each other using fluorescence-activated cell sorting methods. Analysis of the separated cells revealed that stochastic IFNβ expression is a consequence of cell-to-cell variability in the levels and/or activities of limiting components at every level of the virus induction process, ranging from viral replication and expression, to the sensing of viral RNA by host factors, to activation of the signaling pathway, to the levels of activated transcription factors. We propose that this highly complex stochastic IFNβ gene expression evolved to optimize both the level and distribution of type I IFNs in response to virus infection.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line
  • Fibroblasts / immunology*
  • Fibroblasts / virology
  • Flow Cytometry
  • Gene Expression Regulation
  • Genetic Variation
  • Host-Pathogen Interactions
  • Interferon-alpha / biosynthesis
  • Interferon-alpha / genetics
  • Interferon-beta / biosynthesis
  • Interferon-beta / genetics*
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism
  • Mice
  • Nerve Tissue Proteins / genetics
  • Nerve Tissue Proteins / metabolism
  • Poly I-C / genetics
  • Receptors, Cell Surface
  • Recombinant Fusion Proteins / genetics
  • Recombinant Fusion Proteins / immunology
  • Sendai virus / growth & development
  • Sendai virus / immunology*
  • Signal Transduction
  • Stochastic Processes
  • Transcription Factors / genetics
  • Transcription Factors / immunology
  • Transcription, Genetic
  • Virus Replication

Substances

  • Interferon-alpha
  • Membrane Proteins
  • Nerve Tissue Proteins
  • Receptors, Cell Surface
  • Recombinant Fusion Proteins
  • Robo3 protein, mouse
  • Transcription Factors
  • Interferon-beta
  • Poly I-C