Abstract
A pentacyclic triterpene, oleanderocioic acid, two flavonoidal glycosides, quercetin-5-O-[α-L-rhamnopyranosyl-(1→6)]-β-D-glucopyranoside and kaempferol-5-O-[α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside, and a cardenolide, oleandigoside, together with 11 known compounds, were isolated from the leaves of Nerium oleander. Their structures were elucidated on the basis of spectroscopic analysis. The growth inhibitory and cytotoxic activities of eight compounds were evaluated against the MCF-7 human breast cancer cell line using a sulforhodamine B assay. Three compounds, oleandrin, odoroside A and B were further assayed using a panel of 57 human cancer cell lines.
Copyright © 2012 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry*
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / toxicity
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Cardenolides / chemistry*
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Cardenolides / isolation & purification
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Cardenolides / toxicity
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Flavonoids / chemistry*
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Flavonoids / isolation & purification
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Flavonoids / toxicity
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Glycosides / chemistry*
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Glycosides / isolation & purification
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Glycosides / toxicity
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Humans
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MCF-7 Cells
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Nerium / chemistry*
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Nerium / metabolism
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Nuclear Magnetic Resonance, Biomolecular
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Pentacyclic Triterpenes / chemistry*
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Pentacyclic Triterpenes / isolation & purification
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Pentacyclic Triterpenes / toxicity
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Plant Extracts / chemistry
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Plant Leaves / chemistry
Substances
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Antineoplastic Agents, Phytogenic
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Cardenolides
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Flavonoids
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Glycosides
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Pentacyclic Triterpenes
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Plant Extracts