Abstract
Ultraviolet (UV) radiation contained in sunlight is considered a major risk in the induction of skin cancer. While mast cells are best known for their role in allergic responses, they have also been shown to play a crucial role in suppressing the anti-tumour immune response following UV exposure. Evidence is now emerging that UV may also trigger mast cell release of cutaneous tissue remodelling and pro-angiogenic factors. In this review, we will focus on the cellular and molecular mechanisms by which UV recruits and then activates mast cells to initiate and promote skin cancer development.
© 2012 John Wiley & Sons A/S.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Histamine / physiology
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Humans
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Immune Tolerance / radiation effects
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Interleukin-10 / physiology
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Interleukin-4 / physiology
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Mast Cells / immunology
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Mast Cells / pathology
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Mast Cells / physiology
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Mast Cells / radiation effects*
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Models, Biological
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Neoplasms, Radiation-Induced / etiology*
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Neoplasms, Radiation-Induced / immunology
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Neoplasms, Radiation-Induced / pathology
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Neoplasms, Radiation-Induced / physiopathology
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Nerve Growth Factor / physiology
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Neuropeptides / physiology
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Skin Neoplasms / etiology*
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Skin Neoplasms / immunology
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Skin Neoplasms / pathology
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Skin Neoplasms / physiopathology
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Sunlight / adverse effects*
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Transforming Growth Factor beta / physiology
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Tumor Microenvironment / physiology
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Tumor Necrosis Factor-alpha / physiology
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Ultraviolet Rays / adverse effects
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Vascular Endothelial Growth Factor A / physiology
Substances
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IL10 protein, human
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IL4 protein, human
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Neuropeptides
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Transforming Growth Factor beta
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Tumor Necrosis Factor-alpha
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VEGFA protein, human
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Vascular Endothelial Growth Factor A
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Interleukin-10
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Interleukin-4
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Histamine
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Nerve Growth Factor