One-pot synthesis of amides by aerobic oxidative coupling of alcohols or aldehydes with amines using supported gold and base as catalysts

Søren Kegnæs; Jerrik Mielby; Uffe V Mentzel; Thomas Jensen; Peter Fristrup; Anders Riisager

doi:10.1039/c2cc16768a

One-pot synthesis of amides by aerobic oxidative coupling of alcohols or aldehydes with amines using supported gold and base as catalysts

Chem Commun (Camb). 2012 Feb 28;48(18):2427-9. doi: 10.1039/c2cc16768a. Epub 2012 Jan 25.

Authors

Søren Kegnæs¹, Jerrik Mielby, Uffe V Mentzel, Thomas Jensen, Peter Fristrup, Anders Riisager

Affiliation

¹ Centre for Catalysis and Sustainable Chemistry, Department of Chemistry, Technical University of Denmark, Building 207, 2800 Kgs. Lyngby, Denmark.

PMID: 22274843
DOI: 10.1039/c2cc16768a

Abstract

Synthesis of amides by aerobic oxidative coupling of alcohols or aldehydes with amines via intermediate formation of methyl esters is highly efficient and selective when using a catalytic system comprised of supported gold nanoparticles and added base in methanol.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alcohols / chemistry*
Aldehydes / chemistry*
Amides / chemical synthesis*
Amides / chemistry*
Amines / chemistry*
Catalysis
Chemistry Techniques, Synthetic / methods*
Gold / chemistry*
Oxidation-Reduction
Substrate Specificity

Substances

Alcohols
Aldehydes
Amides
Amines
Gold