Abstract
Global dissemination of imipenem-resistant (IR) clones of Acinetobacter baumannii - A. calcoaceticus complex (ABC) have been frequently reported but the molecular epidemiological features of IR-ABC in military treatment facilities (MTFs) have not been described. We characterized 46 IR-ABC strains from a dataset of 298 ABC isolates collected from US service members hospitalized in different US MTFs domestically and overseas during 2003-2008. All IR strains carried the bla(OXA-51) gene and 40 also carried bla(OXA-23) on plasmids and/or chromosome; one carried bla(OXA-58) and four contained ISAbal located upstream of bla(OXA-51). Strains tended to cluster by pulsed-field gel electrophoresis profiles in time and location. Strains from two major clusters were identified as international clone I by multilocus sequence typing.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Acinetobacter Infections / drug therapy
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Acinetobacter Infections / epidemiology
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Acinetobacter Infections / microbiology*
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Acinetobacter baumannii / classification
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Acinetobacter baumannii / genetics*
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Acinetobacter calcoaceticus / classification
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Acinetobacter calcoaceticus / genetics
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Anti-Bacterial Agents / therapeutic use*
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Electrophoresis, Gel, Pulsed-Field
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Germany / epidemiology
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Humans
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Imipenem / therapeutic use*
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Iraq War, 2003-2011
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Microbial Sensitivity Tests
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Military Personnel
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Molecular Epidemiology
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Multilocus Sequence Typing
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Phylogeography
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United States / epidemiology
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beta-Lactam Resistance*
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beta-Lactamases / genetics*
Substances
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Anti-Bacterial Agents
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Imipenem
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beta-lactamase OXA-23
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beta-Lactamases
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beta-lactamase OXA-143, Acinetobacter baumannii
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beta-lactamase OXA-24
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beta-lactamase OXA-40, Acinetobacter baumannii
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beta-lactamase OXA-51, Acinetobacter baumannii
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beta-lactamase OXA-58, Acinetobacter baumannii