Polymorphisms of innate immunity genes influence disease progression in HIV-1-infected children

AIDS. 2012 Mar 27;26(6):765-8. doi: 10.1097/QAD.0b013e3283514350.

Abstract

Toll-like receptors (TLRs) and defensins (DEFs) play a crucial role in the host's innate immunity and may influence HIV-1 disease progression. We investigated the impact of TLR9 +1174G > A, 1635A > G and DEFβ1 -44C > G, -52G > A single nucleotide polymorphisms on the clinical outcome of 95 HIV-1-infected children. The TLR9 1635AG genotype and TLR9 [G;G] haplotype were associated with rapid disease progression, whereas the DEFβ1 -44CG genotype and DEFβ1 [G;G] haplotype correlated with a better clinical outcome.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Child
  • Child, Preschool
  • Disease Progression
  • Genetic Predisposition to Disease
  • HIV Infections / genetics*
  • HIV Infections / immunology
  • HIV-1
  • Humans
  • Immunity, Innate / genetics*
  • Infant
  • Infant, Newborn
  • Polymorphism, Single Nucleotide / genetics*
  • Toll-Like Receptor 9 / genetics*
  • beta-Defensins / genetics*

Substances

  • DEFB1 protein, human
  • TLR9 protein, human
  • Toll-Like Receptor 9
  • beta-Defensins