Costameric proteins: from benchside to future translational cardiovascular research

Giuseppina Cutroneo; Salvatore Lentini; Angelo Favaloro; Giuseppe Anastasi; Debora Di Mauro

doi:10.1016/j.ancard.2011.12.003

Costameric proteins: from benchside to future translational cardiovascular research

Ann Cardiol Angeiol (Paris). 2012 Feb;61(1):55-60. doi: 10.1016/j.ancard.2011.12.003. Epub 2011 Dec 27.

Authors

Giuseppina Cutroneo¹, Salvatore Lentini, Angelo Favaloro, Giuseppe Anastasi, Debora Di Mauro

Affiliation

¹ Department of Biomorphology and Biotechnologies, School of Medicine, University of Messina, Messina, Italy.

PMID: 22264821
DOI: 10.1016/j.ancard.2011.12.003

Abstract

Costameres encircle the myocyte perpendicular to its long axis, and comprise two protein complexes: the dystrophin-glycoprotein complex (DGC) and the vinculin-talin-integrin system. They participate in signaling functions and protect muscle cells from damage induced by workload. The behaviour of those proteins has been a focus of study starting from skeletal and smooth muscle cells to cardiomyocytes, and still represents a topical subject for cardiovascular translational research. This review summarizes the past and present novel approaches of our and other groups of work on this subject of research.

Publication types

Review

MeSH terms

Cardiovascular System / ultrastructure*
Costameres*
Forecasting
Humans
Muscle Proteins* / ultrastructure
Muscle, Skeletal / ultrastructure
Muscle, Smooth / ultrastructure
Myocytes, Cardiac / ultrastructure
Translational Research, Biomedical* / trends

Substances

Muscle Proteins