Abstract
A series of 5-aryl-1,4-benzodiazepines with chloro- or fluoro-substituents in the second ring have been synthesized and their anti-inflammatory, myeloperoxidase and anticancer properties studied. The synthesized compounds showed potential anti-inflammatory and anticancer activities, which were enhanced in the presence of a chloro-substituent in the second ring of the 5-aryl-1,4- benzodiazepine.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Inflammatory Agents / chemical synthesis*
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Anti-Inflammatory Agents / pharmacology
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology
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Benzodiazepines / chemical synthesis*
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Benzodiazepines / pharmacology
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Cell Line, Tumor
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Crystallography, X-Ray
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Dose-Response Relationship, Drug
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Edema / drug therapy
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Female
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Halogenation
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Humans
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Inflammation / drug therapy
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Inhibitory Concentration 50
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Male
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Mice
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Neoplasms / drug therapy
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Neoplasms / pathology
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Peroxidase / antagonists & inhibitors*
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Peroxidase / metabolism
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Structure-Activity Relationship
Substances
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Anti-Inflammatory Agents
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Antineoplastic Agents
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Benzodiazepines
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Peroxidase