This article illustrates the value of specific prescribing practices in three important areas--treatment adherence, prevention of suicide by overdose/accidental overdose, and communication and accountability--in achieving the safe and seamless discharge of psychiatric patients from an inpatient psychiatry unit. Psychiatric patients are at particular risk for adverse clinical events upon discharge from the hospital. Achieving safe and effective prescribing practices in mental health care requires an understanding of the elements that contribute to a patient's successful discharge from an inpatient unit. The implementation of specific prescribing practices, such as open communication with patients and families and collaboration among healthcare providers, can improve adherence to treatment, reduce the risk of overdose and suicide, ensure a seamless transition to the next provider of care, and facilitate best outcomes for patients.