Unobtrusive monitoring of the cardio-respiratory and daily activity for wheelchair users became nowadays an important challenge, considering population aging phenomena and the increasing of the elderly with chronic diseases that affect their motion capabilities. This work reports the utilization of FMCW (frequency modulated continuous wave) Doppler radar sensors embedded in a manual wheelchair to measure the cardiac and respiratory activities and the physical activity of the wheelchair user. Another radar sensor is included in the system in order to quantify the motor activity through the wheelchair traveled distance, when the user performs the manual operation of the wheelchair. A conditioning circuit including active filters and a microcontroller based primary processing module was designed and implemented to deliver the information through Bluetooth communication protocol to an Android OS tablet computer. The main capabilities of the software developed using Android SDK and Java were the signal processing of Doppler radar measurement channel signals, graphical user interface, data storage and Wi-Fi data synchronization with remote physiological and physical activity database.