Monitoring healthy metabolic trajectories with nutritional metabonomics

Nutrients. 2009 Jan;1(1):101-10. doi: 10.3390/nu1010101. Epub 2009 Sep 4.

Abstract

Metabonomics is a well established analytical approach for the analysis of physiological regulatory processes via the metabolic profiling of biofluids and tissues in living organisms. Its potential is fully exploited in the field of "nutrimetabonomics" that aims at assessing the metabolic effects of active ingredients and foods in individuals. Yet, one of the greatest challenges in nutrition research is to decipher the critical interactions between mammalian organisms and environmental factors, including the gut microbiota. "Nutrimetabonomics" is today foreseen as a powerful approach for future nutritional programs tailored at health maintenance and disease prevention.

Keywords: GC (Gas Chromatography); MS (Mass Spectrometry); NMR (Nuclear Magnetic Resonance) Spectroscopy; UPLC (Ultra Performance Liquid Chromatography); gut microbiota; metabolomics; metabonomics; metabotypes; nutrimetabonomics; personalized nutrition.

Publication types

  • Review

MeSH terms

  • Food Analysis / methods*
  • Gastrointestinal Tract / microbiology*
  • Humans
  • Magnetic Resonance Spectroscopy / methods
  • Mass Spectrometry / methods
  • Metabolome
  • Metabolomics / methods*
  • Metagenome*
  • Nutritional Physiological Phenomena / physiology*