This article reports a 1:2 matched case-control study on 80 cases of bladder cancer in Heilongjiang province. Multiple logistic regression analysis for risk state suggested that three factors, i.e., cigarette smoking, use of saccharin and reduced intake of vegetables are closely associated with development of bladder cancer. Giving up smoking, using no saccharin and eating more fresh vegetables are main ways to reduce the incidence of bladder cancer.