LTR retrotransposons in fungi

PLoS One. 2011;6(12):e29425. doi: 10.1371/journal.pone.0029425. Epub 2011 Dec 29.

Abstract

Transposable elements with long terminal direct repeats (LTR TEs) are one of the best studied groups of mobile elements. They are ubiquitous elements present in almost all eukaryotic genomes. Their number and state of conservation can be a highlight of genome dynamics. We searched all published fungal genomes for LTR-containing retrotransposons, including both complete, functional elements and remnant copies. We identified a total of over 66,000 elements, all of which belong to the Ty1/Copia or Ty3/Gypsy superfamilies. Most of the detected Gypsy elements represent Chromoviridae, i.e. they carry a chromodomain in the pol ORF. We analyzed our data from a genome-ecology perspective, looking at the abundance of various types of LTR TEs in individual genomes and at the highest-copy element from each genome. The TE content is very variable among the analyzed genomes. Some genomes are very scarce in LTR TEs (<50 elements), others demonstrate huge expansions (>8000 elements). The data shows that transposon expansions in fungi usually involve an increase both in the copy number of individual elements and in the number of element types. The majority of the highest-copy TEs from all genomes are Ty3/Gypsy transposons. Phylogenetic analysis of these elements suggests that TE expansions have appeared independently of each other, in distant genomes and at different taxonomical levels. We also analyzed the evolutionary relationships between protein domains encoded by the transposon pol ORF and we found that the protease is the fastest evolving domain whereas reverse transcriptase and RNase H evolve much slower and in correlation with each other.

MeSH terms

  • Base Sequence
  • Cluster Analysis
  • Databases, Genetic
  • Evolution, Molecular
  • Fungi / enzymology
  • Fungi / genetics*
  • Genome, Fungal / genetics
  • Integrases / chemistry
  • Integrases / genetics
  • Likelihood Functions
  • Peptide Hydrolases / chemistry
  • Peptide Hydrolases / genetics
  • Protein Structure, Tertiary
  • RNA-Directed DNA Polymerase / chemistry
  • RNA-Directed DNA Polymerase / genetics
  • Retroelements / genetics*
  • Ribonuclease H / chemistry
  • Ribonuclease H / genetics
  • Terminal Repeat Sequences / genetics*

Substances

  • Retroelements
  • Integrases
  • RNA-Directed DNA Polymerase
  • Ribonuclease H
  • Peptide Hydrolases