Abstract
In a study performed in Cambodia, a higher number of tuberculosis (TB) strains with mutations in the pncA gene associated with pyrazinamide resistance (PZA-R) was found in fluoroquinolone-resistant (FQ-R) multidrug-resistant (MDR) strains (93%), compared with 47% in MDR and 3% in non-MDR strains. This emphasises the need for easy and rapid tests for identification of PZA-R for efficient treatment of MDR-TB.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Amidohydrolases / genetics*
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Antitubercular Agents / therapeutic use
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Cambodia / epidemiology
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DNA, Bacterial / genetics*
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Fluoroquinolones / therapeutic use*
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Genotype
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Humans
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Incidence
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Mutation*
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Mycobacterium tuberculosis / drug effects
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Mycobacterium tuberculosis / genetics*
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Mycobacterium tuberculosis / isolation & purification
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Pyrazinamide / therapeutic use*
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Retrospective Studies
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Tuberculosis, Multidrug-Resistant / drug therapy*
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Tuberculosis, Multidrug-Resistant / epidemiology
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Tuberculosis, Multidrug-Resistant / microbiology
Substances
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Antitubercular Agents
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DNA, Bacterial
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Fluoroquinolones
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Pyrazinamide
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Amidohydrolases
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PncA protein, Mycobacterium tuberculosis