[Analysis association of acute ischemic stroke and DNA markers in Russian and Moldavian populations]

E A Bondarenko; I M Shetova; N A Shamalov; E I Mokan; N I Barbakar; G S Kurochkin; S S Protopop; L T Lysyĭ; P A SlominskIĭ; S A Limborskaia; V I Skvortsova

[Analysis association of acute ischemic stroke and DNA markers in Russian and Moldavian populations]

Genetika. 2011 Oct;47(10):1393-401.

[Article in Russian]

Authors

E A Bondarenko, I M Shetova, N A Shamalov, E I Mokan, N I Barbakar, G S Kurochkin, S S Protopop, L T Lysyĭ, P A SlominskIĭ, S A Limborskaia, V I Skvortsova

PMID: 22232928

Abstract

Polymorphisms c.202G > A of prothrombin F2 gene, c.1691G > A of coagulation factor V F5 gene, c.675delinsG of plasminogen activator1 gene, and (-5)T > C Kozak gene of thrombocytic receptor were studied in the Russian and Moldavian ethnic groups. We have found no association between these polymorphisms and the risk of ischemic stroke development in both ethnic groups. No association was revealed between the risk of stroke development and various combinations of the single nucleotide polymorphisms examined in the sample of ischemic stroke patients from Russia.

Publication types

English Abstract

MeSH terms

Adult
Brain Ischemia / genetics*
Brain Ischemia / pathology
Case-Control Studies
Factor V / genetics*
Female
Gene Frequency
Genetic Association Studies
Genetic Markers
Humans
Male
Membrane Glycoproteins / genetics*
Moldova
Plasminogen Activator Inhibitor 1 / genetics*
Platelet Glycoprotein GPIb-IX Complex
Polymorphism, Genetic
Polymorphism, Single Nucleotide
Prothrombin / genetics*
Russia
Stroke / genetics*
Stroke / pathology

Substances

Genetic Markers
Membrane Glycoproteins
Plasminogen Activator Inhibitor 1
Platelet Glycoprotein GPIb-IX Complex
SERPINE1 protein, human
adhesion receptor
Factor V
Prothrombin