Abstract
Cinnamomum cambodianum has been used as a traditional medicine in Cambodia. Its effect on the bone marrow-derived mast cells (BMMCs) mediated allergic response remains unknown. In this study, a chloroform-soluble extract of C. cambodianum was evaluated for its effect on allergic mediators, including prostaglandin D₂ (PGD₂), leukotriene C₄ (LTC₄), β-hexosaminidase and cyclooxygenase-2 (COX-2) protein, in phorbol 12-myristate 13-acetate (PMA) plus calcimycin-stimulated BMMCs. The results revealed that the chloroform-soluble extract inhibited the production of interleukin-6, PGD₂ and LTC₄, and the expression of COX-2 in PMA plus calcimycin-stimulated BMMCs, implying a potential benefit of C. cambodianum in the treatment of allergy.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Bone Marrow Cells / immunology*
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Bone Marrow Cells / metabolism
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Calcimycin / pharmacology
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Calcium Ionophores / pharmacology
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Carcinogens / pharmacology
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Chloroform / chemistry*
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Cinnamomum / chemistry*
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Complex Mixtures* / chemistry
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Complex Mixtures* / pharmacology
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Cyclooxygenase 2 / biosynthesis
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Cyclooxygenase 2 / immunology
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Female
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Gene Expression Regulation, Enzymologic / drug effects
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Gene Expression Regulation, Enzymologic / immunology
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Hypersensitivity / drug therapy*
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Hypersensitivity / immunology
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Hypersensitivity / metabolism
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Interleukin-6 / immunology
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Interleukin-6 / metabolism
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Leukotriene C4 / immunology
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Leukotriene C4 / metabolism
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Mast Cells / immunology*
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Mast Cells / metabolism
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Mice
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Mice, Inbred BALB C
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Prostaglandin D2 / immunology
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Prostaglandin D2 / metabolism
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Tetradecanoylphorbol Acetate / pharmacology
Substances
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Calcium Ionophores
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Carcinogens
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Complex Mixtures
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Interleukin-6
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Leukotriene C4
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Calcimycin
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Chloroform
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Ptgs2 protein, mouse
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Cyclooxygenase 2
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Tetradecanoylphorbol Acetate
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Prostaglandin D2