Simple scale-up of recombinant antibody production using an UCOE containing vector

Sabrina Boscolo; Francesca Mion; Marta Licciulli; Paolo Macor; Luca De Maso; Martina Brce; Michael N Antoniou; Roberto Marzari; Claudio Santoro; Daniele Sblattero

doi:10.1016/j.nbt.2011.12.005

Simple scale-up of recombinant antibody production using an UCOE containing vector

N Biotechnol. 2012 May 15;29(4):477-84. doi: 10.1016/j.nbt.2011.12.005. Epub 2011 Dec 28.

Authors

Sabrina Boscolo¹, Francesca Mion, Marta Licciulli, Paolo Macor, Luca De Maso, Martina Brce, Michael N Antoniou, Roberto Marzari, Claudio Santoro, Daniele Sblattero

Affiliation

¹ Department of Life Sciences - University of Trieste, Italy.

PMID: 22226921
DOI: 10.1016/j.nbt.2011.12.005

Abstract

Recombinant proteins, in particular antibodies, have become fundamental in biomedical research where they are used in numerous therapeutic and diagnostic applications. For this reason there is an increasing demand for quick and economical production systems for recombinant proteins in mammalian cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antibody Formation
CHO Cells
Cricetinae
Cricetulus
Genetic Vectors / metabolism*
Recombinant Fusion Proteins / biosynthesis
Recombinant Fusion Proteins / genetics
Single-Chain Antibodies / biosynthesis*
Single-Chain Antibodies / genetics

Substances

Recombinant Fusion Proteins
Single-Chain Antibodies