Synthesis and biological evaluation of benzo[d]imidazole derivatives as potential anti-cancer agents

Hamad M Alkahtani; Abdullahi Y Abbas; Shudong Wang

doi:10.1016/j.bmcl.2011.12.088

Synthesis and biological evaluation of benzo[d]imidazole derivatives as potential anti-cancer agents

Bioorg Med Chem Lett. 2012 Feb 1;22(3):1317-21. doi: 10.1016/j.bmcl.2011.12.088. Epub 2011 Dec 23.

Authors

Hamad M Alkahtani¹, Abdullahi Y Abbas, Shudong Wang

Affiliation

¹ School of Pharmacy and Centre for Biomolecular Sciences, University of Nottingham, Nottingham NG7 2RD, UK.

PMID: 22225635
DOI: 10.1016/j.bmcl.2011.12.088

Abstract

We herein report the synthesis, biological activity and structure-activity relationship of derivatives of 5,6-dichloro-1-β-D-ribofuranosylbenzimidazole and benzo[d]imidazole. A lead compound 6o demonstrates potent anti-proliferative activity and the ability to induce cancer cell apoptosis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Apoptosis / drug effects*
Blotting, Western
Cell Proliferation / drug effects
Drug Screening Assays, Antitumor
HCT116 Cells
Humans
Imidazoles / chemical synthesis*
Imidazoles / chemistry
Imidazoles / pharmacology*
Molecular Structure
Structure-Activity Relationship

Substances

Antineoplastic Agents
Imidazoles