Polyelectrolyte complex materials consisting of antibacterial and cell-supporting layers

Macromol Biosci. 2012 Mar;12(3):374-82. doi: 10.1002/mabi.201100317. Epub 2011 Dec 30.

Abstract

The characterization of a polyelectrolyte complex material comprised of two biopolymers, a chitosan upper layer and a gellan gum under layer, is reported. It is shown that the upper layer of chitosan with incorporated levofloxacin displays an antibacterial activity, while the under layer of a gellan gum/TiO(2) composite supports the growth of fibroblastic cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology
  • Biocompatible Materials / chemical synthesis*
  • Biocompatible Materials / pharmacology
  • Cell Proliferation / drug effects
  • Cell Survival / drug effects
  • Chitosan / chemistry*
  • Drug Compounding
  • Escherichia coli / drug effects
  • Fibroblasts / cytology
  • Fibroblasts / drug effects
  • Levofloxacin*
  • Microbial Viability / drug effects
  • Ofloxacin / chemistry
  • Ofloxacin / pharmacology*
  • Polysaccharides, Bacterial / chemistry*
  • Titanium / chemistry

Substances

  • Anti-Bacterial Agents
  • Biocompatible Materials
  • Polysaccharides, Bacterial
  • titanium dioxide
  • Levofloxacin
  • gellan gum
  • Chitosan
  • Ofloxacin
  • Titanium