Peripheral administration of poly I:C disrupts contextual fear memory consolidation and BDNF expression in mice

Dinko Kranjac; Kristina A McLinden; Kyle M Koster; David L Kaldenbach; Michael J Chumley; Gary W Boehm

doi:10.1016/j.bbr.2011.12.031

Peripheral administration of poly I:C disrupts contextual fear memory consolidation and BDNF expression in mice

Behav Brain Res. 2012 Mar 17;228(2):452-7. doi: 10.1016/j.bbr.2011.12.031. Epub 2011 Dec 27.

Authors

Dinko Kranjac¹, Kristina A McLinden, Kyle M Koster, David L Kaldenbach, Michael J Chumley, Gary W Boehm

Affiliation

¹ Department of Psychology, Texas Christian University, Fort Worth, TX 76129, USA.

PMID: 22222172
DOI: 10.1016/j.bbr.2011.12.031

Abstract

In the current study, administration of poly I:C induced a deficit in contextual, but not auditory-cue, fear memory consolidation. This memory deficit coincided with a decrease in hippocampal and cortical BDNF mRNA expression. These results extend prior work, and suggest that a single peripheral injection of poly I:C disrupts contextual fear memory consolidation processes in adult mice, and that these deficits may potentially be mediated by diminished BDNF expression.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Analysis of Variance
Animals
Brain-Derived Neurotrophic Factor / genetics
Brain-Derived Neurotrophic Factor / metabolism*
Conditioning, Psychological / drug effects*
Cytokines / metabolism
Fear / drug effects*
Freezing Reaction, Cataleptic / drug effects
Gene Expression Regulation / drug effects
Memory Disorders / chemically induced*
Mice
Mice, Inbred C57BL
Poly I-C / adverse effects*
RNA, Messenger / metabolism
Time Factors

Substances

Brain-Derived Neurotrophic Factor
Cytokines
RNA, Messenger
Poly I-C