Alcohol-responsive writer's cramp

Intern Med. 2012;51(1):99-101. doi: 10.2169/internalmedicine.51.6322. Epub 2012 Jan 1.

Abstract

Writer's cramp is a rare movement disorder of unknown etiology, in which a cramp is elicited primarily or exclusively with writing. We describe a patient with primary writer's cramp that was completely improved by drinking a small amount of alcohol. Although it is unclear how "alcohol" ameliorated the dystonia, this case suggests that alcohol might reverse the pathophysiologic changes in the entire basal ganglia circuit. In addition, we cannot rule out the possibility that the anxiolytic influence of alcohol may contribute to the beneficial effects on dystonia.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Alcohol Drinking / physiopathology
  • Brain / drug effects
  • Brain / physiopathology
  • Dystonic Disorders / drug therapy*
  • Dystonic Disorders / physiopathology
  • Electromyography
  • Ethanol / therapeutic use*
  • Female
  • Humans
  • gamma-Aminobutyric Acid / physiology

Substances

  • Ethanol
  • gamma-Aminobutyric Acid