Controlled acid hydrolysis and acetylation of glucomannans as drug carriers with designed pharmacokinetic behaviors

J Control Release. 2011 Nov 30:152 Suppl 1:e61-2. doi: 10.1016/j.jconrel.2011.08.123.

Authors

Jiangyun Liu¹, Yan Zhang, Yin Yin, Fang Peng, Peilie Cai, Shilin Yang

Affiliation

¹ Department of Medicinal Chemistry, School of Pharmacy, Medical College of Soochow University, Suzhou 215123, China. jiangyunliu@yahoo.com.cn

PMID: 22195928
DOI: 10.1016/j.jconrel.2011.08.123

No abstract available

MeSH terms

Acetylation
Animals
Chemistry, Pharmaceutical
Chromatography, High Pressure Liquid
Delayed-Action Preparations
Drug Carriers*
Drug Compounding
Half-Life
Hydrogen-Ion Concentration
Hydrolysis
Injections, Intravenous
Magnetic Resonance Spectroscopy
Mannans / administration & dosage
Mannans / blood
Mannans / chemistry
Mannans / pharmacokinetics*
Metabolic Clearance Rate
Molecular Weight
Rabbits
Solubility
Spectrophotometry, Infrared
Technology, Pharmaceutical / methods

Substances

Delayed-Action Preparations
Drug Carriers
Mannans
(1-6)-alpha-glucomannan