NDM-2 carbapenemase-producing Acinetobacter baumannii in the United Arab Emirates

Clin Microbiol Infect. 2012 Feb;18(2):E34-6. doi: 10.1111/j.1469-0691.2011.03726.x. Epub 2011 Dec 22.

Abstract

Screening 155 carbapenem non-susceptible Acinetobacter baumannii strains recovered in Abu Dhabi hospitals identified two metallo-ß-lactamase bla(NDM) gene-carrying isolates. They were isolated 4 months apart from the urine of a cancer patient previously treated in Egypt, Lebanon and in the United Arab Emirates. They were clonally related and carried the bla(NDM-2) gene recently identified in A. baumannii in Egypt and Israel. Sequences surrounding the bla(NDM-2) gene showed significant similarities with those associated with bla(NDM-1) in Enterobacteriaceae and A. baumannii. Repeated isolation of bla(NDM-2)-positive A. baumannii in the Middle East raises the possibility of the local emergence and spread of a unique clone.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acinetobacter Infections / microbiology*
  • Acinetobacter baumannii / drug effects
  • Acinetobacter baumannii / enzymology*
  • Acinetobacter baumannii / isolation & purification
  • Bacterial Proteins / genetics*
  • Bacterial Proteins / metabolism
  • Carbapenems / pharmacology*
  • DNA, Bacterial / chemistry
  • DNA, Bacterial / genetics
  • Female
  • Genotype
  • Humans
  • Middle Aged
  • Molecular Sequence Data
  • Molecular Typing
  • Neoplasms / complications
  • Sequence Analysis, DNA
  • United Arab Emirates
  • Urine / microbiology
  • beta-Lactam Resistance*
  • beta-Lactamases / genetics*
  • beta-Lactamases / metabolism

Substances

  • Bacterial Proteins
  • Carbapenems
  • DNA, Bacterial
  • beta-Lactamases
  • carbapenemase

Associated data

  • GENBANK/JN112341