Abstract
Background:
In the present study, an activity of Bixa orellana extract against Leishmania amazonensis was demonstrated.
Result:
Experimentally infected BALB/c mice were treated with B. orellana extract which showed a significant activity against promastigote and amastigote forms of L. amazonensis.
Conclusion:
This study supports the importance of natural sources as antileishmanial drugs.
Copyright © 2011 S. Karger AG, Basel.
MeSH terms
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Amphotericin B / pharmacology
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Animals
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Antiprotozoal Agents / pharmacology*
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Antiprotozoal Agents / therapeutic use*
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Bixaceae / chemistry*
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Body Weight / drug effects
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Cell Survival / drug effects
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Female
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Inhibitory Concentration 50
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Leishmania / drug effects*
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Leishmaniasis / drug therapy*
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Life Cycle Stages / drug effects
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Macrophages, Peritoneal / cytology
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Macrophages, Peritoneal / parasitology
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Mice
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Mice, Inbred BALB C
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Plant Extracts / pharmacology*
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Plant Extracts / therapeutic use*
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Random Allocation
Substances
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Antiprotozoal Agents
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Plant Extracts
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Amphotericin B