A mammalian like interleukin-1 receptor-associated kinase 4 (IRAK-4), a TIR signaling mediator in intestinal innate immunity of black tiger shrimp (Penaeus monodon)

Biochem Biophys Res Commun. 2012 Jan 6;417(1):623-9. doi: 10.1016/j.bbrc.2011.12.019. Epub 2011 Dec 11.

Abstract

Interleukin-1 receptor associated kinase-4 (IRAK-4) has been identified as a central signal transduction mediator of the Toll-like receptor (TLR) and Toll/interleukin-1 receptor (TIR) pathways in vertebrate innate immunity. An IRAK-4 homologue was cloned from the black tiger shrimp (Penaeus monodon) (PmIRAK-4) and it shares domains and structures with other IRAK-4s. It was found to be mainly expressed in the hemocytes and midgut but also to a lower extent in several other tissues in shrimp. The PmIRAK-4 responded to bacterial infection in the intestine by an enhancement of its expression level. These results indicate that PmIRAK-4 may play a role at least in the intestinal innate immunity of P. monodon.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Immunity, Innate*
  • Interleukin-1 Receptor-Associated Kinases / classification
  • Interleukin-1 Receptor-Associated Kinases / genetics
  • Interleukin-1 Receptor-Associated Kinases / metabolism*
  • Molecular Sequence Data
  • Penaeidae / enzymology
  • Penaeidae / immunology*
  • Phylogeny
  • Protein Structure, Secondary
  • Toll-Like Receptors / classification
  • Toll-Like Receptors / genetics
  • Toll-Like Receptors / metabolism*

Substances

  • Toll-Like Receptors
  • Interleukin-1 Receptor-Associated Kinases