Abstract
The synthesis of mesoporous silica nanoparticles (MSN) covalently encapsulating fluoresceine or a photosensitizer, functionalized with galactose on the surface is described. Confocal microscopy experiments demonstrated that the uptake of galactose-functionalized MSN by colorectal cancer cells was mediated by galactose receptors leading to the accumulation of the nanoparticles in the endosomal and lysosomal compartments. The MSN functionalized with a photosensitizer and galactose were loaded with the anti-cancer drug camptothecin. Those MSN combining drug delivery and photodynamic therapy were tested on three cancer cell lines and showed a dramatic enhancement of cancer cell death compared to separate treatments.
Copyright © 2011 Elsevier B.V. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Death / drug effects
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Chemistry, Pharmaceutical
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Drug Carriers*
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Drug Compounding
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Endosomes / metabolism
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Fluorescein / chemistry
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Fluorescein / metabolism
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Galactose / chemistry
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Galactose / metabolism*
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HCT116 Cells
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Humans
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Lysosomes / metabolism
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Microscopy, Confocal
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Nanoparticles*
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Nanotechnology
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Neoplasms / metabolism
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Neoplasms / pathology
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Photochemotherapy*
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Photosensitizing Agents / chemistry
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Photosensitizing Agents / metabolism
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Photosensitizing Agents / pharmacology*
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Porosity
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Receptors, Cell Surface / metabolism
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Silicon Dioxide / chemistry*
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Technology, Pharmaceutical / methods
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Time Factors
Substances
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Drug Carriers
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Photosensitizing Agents
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Receptors, Cell Surface
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galactose receptor
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Silicon Dioxide
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Fluorescein
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Galactose