Face-to-face, pak-to-pak

Kimberly A Malecka; Jeffrey R Peterson

doi:10.1016/j.str.2011.11.007

Face-to-face, pak-to-pak

Structure. 2011 Dec 7;19(12):1723-4. doi: 10.1016/j.str.2011.11.007.

Authors

Kimberly A Malecka¹, Jeffrey R Peterson

Affiliation

¹ Cancer Biology Program, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA.

PMID: 22153490
DOI: 10.1016/j.str.2011.11.007

Abstract

Biochemical and structural studies of p21-activated kinase 1 (Pak1) by Wang and colleagues in this issue of Structure reveal the structural basis for Pak1 trans-autophosphorylation of the activation loop, a critical step in the activation of kinases.

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