As the leading cause of cancer-related death among human beings, lung cancer seriously threats peoples' health all over the world. Cytokine-induced killer cells (CIK) is a new kind of adaptive immune cells characterized by its dramatic proliferation ability and cytotoxicity, non-major histocompatibility antigens (MHC) restriction and low side effects, which draw an increasing attention in recent years. The review is to introduce the basic features and mechanism of CIK cells briefly and summarize the researches of CIK cells used in the clinical therapy for lung cancer. Finally, we discuss several problems that should be addressed before CIK cells are widely applied to clinical patients.
肺癌作为恶性肿瘤导致死亡的首要原因, 严重影响人类的健康。由于细胞因子诱导的杀伤细胞(cytokine-induced killer cells, CIK)强大的增殖活性和细胞毒活性、非主要组织相容性复合体(major histocompatibility antigens, MHC)限制性以及低毒副作用等优点成为近年研究的热点。本文旨在介绍CIK细胞的基本特征及发挥作用的机制, 综述CIK细胞用于肺癌治疗的研究进展, 讨论CIK细胞大规模用于临床前需要解决的若干问题并作出展望。