Abstract
A new bis schiffbases, 3 a-b were synthesized compound 2 with various bis aldehydes. Compounds 3 a-b have been reduced with NaBH(4) to afford the corresponding bis amino triazole compounds 4 a-b. The obtained products 3 a-b and 4 a-b were identified by FTIR, (1)H-NMR, (13)C-NMR. A series of triazol derivatives were evaluated for their antibacterial, antioxidant, antiurease and antielastase activities. The results showed that the synthesized new bis-1,2,4-triazole derivatives had effective antioxidant, antiurease and antielastase activities.
MeSH terms
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Alkenes / chemistry
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Antioxidants / chemical synthesis*
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Antioxidants / chemistry
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Antioxidants / pharmacology*
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Chemistry Techniques, Synthetic
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Drug Evaluation, Preclinical / methods
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Enzyme Inhibitors / chemical synthesis
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology*
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Inhibitory Concentration 50
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Magnetic Resonance Spectroscopy
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Pancreatic Elastase / antagonists & inhibitors*
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Pancreatic Elastase / metabolism
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Spectroscopy, Fourier Transform Infrared
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Structure-Activity Relationship
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Triazoles / chemistry*
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Urease / antagonists & inhibitors*
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Urease / metabolism
Substances
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Alkenes
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Anti-Bacterial Agents
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Antioxidants
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Enzyme Inhibitors
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Triazoles
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butylene
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1,2,4-triazole
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Pancreatic Elastase
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Urease