Abstract
The conformational behaviour and GABA receptor activity of the different stereoisomers of 2,3-difluoro-4-aminobutyric acid are described. Two enantiomeric GABA(C)-active ligands are identified, one of which is an agonist while the other is an antagonist. The results support an existing QSAR model of the bioactive geometry of GABA at GABA(C).
This journal is © The Royal Society of Chemistry 2012
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aminobutyrates / chemistry*
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Aminobutyrates / metabolism
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Animals
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GABA Agonists / chemistry*
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GABA Agonists / metabolism
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GABA Antagonists / chemistry*
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GABA Antagonists / metabolism
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Molecular Conformation
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Oocytes / metabolism
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Quantitative Structure-Activity Relationship
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Receptors, GABA / chemistry*
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Receptors, GABA / metabolism
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Stereoisomerism
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Xenopus
Substances
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Aminobutyrates
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GABA Agonists
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GABA Antagonists
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GABA-C receptor
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Receptors, GABA