The interplay between mutasynthesis and semisynthesis: generation and evaluation of an ansamitocin library

Angew Chem Int Ed Engl. 2012 Jan 16;51(3):752-7. doi: 10.1002/anie.201106249. Epub 2011 Dec 1.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Actinomycetales / genetics
  • Actinomycetales / metabolism
  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / metabolism
  • Antineoplastic Agents / pharmacology*
  • Benzoquinones / chemical synthesis
  • Benzoquinones / chemistry*
  • Benzoquinones / metabolism
  • Benzoquinones / pharmacology*
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Humans
  • Lactams, Macrocyclic / chemical synthesis
  • Lactams, Macrocyclic / chemistry*
  • Lactams, Macrocyclic / metabolism
  • Lactams, Macrocyclic / pharmacology*
  • Maytansine / analogs & derivatives*
  • Maytansine / chemical synthesis
  • Maytansine / chemistry
  • Maytansine / metabolism
  • Maytansine / pharmacology
  • Mutation
  • Neoplasms / drug therapy
  • Streptomyces / genetics
  • Streptomyces / metabolism
  • Tubulin Modulators / chemical synthesis
  • Tubulin Modulators / chemistry
  • Tubulin Modulators / metabolism
  • Tubulin Modulators / pharmacology

Substances

  • Antineoplastic Agents
  • Benzoquinones
  • Lactams, Macrocyclic
  • Tubulin Modulators
  • Maytansine
  • ansamitocins
  • geldanamycin