Abstract
β-Hairpin peptides were conformationally stabilized through a 1,4 disubstituted 1,2,3-triazole interstrand linkage. A NMR conformational analysis revealed that the β-hairpin content depends on the number and position of substituent methylene units of the 1,2,3-triazole ring. These results will allow the design of metabolically stable peptidomimetic analogs of bioactive β-hairpin peptides.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Chemistry, Pharmaceutical / methods*
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Magnetic Resonance Spectroscopy
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Methane / analogs & derivatives
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Methane / chemistry
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Peptides / analysis
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Peptides / chemistry*
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Peptidomimetics / analysis
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Peptidomimetics / chemical synthesis*
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Protein Folding
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Protein Structure, Secondary
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Proteins / analysis
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Proteins / chemistry*
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Triazoles / chemistry*
Substances
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Peptides
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Peptidomimetics
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Proteins
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Triazoles
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Trpzip2 protein
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methylene radical
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Methane