Abstract
Bioassay-guided isolation of bioactive metabolites from the ethyl acetate extract of a marine Bacillus sp. fermentation broth has led to the discovery of three new 24-membered macrolactones, macrolactins 1-3, which contain an oxetane, an epoxide, and a tetrahydropyran ring, respectively. The configurations of 1-3 were assigned by a combination of coupling constants, ROESY data analysis, and application of the modified Mosher's method. Compounds 1-3 showed in vitro antimicrobial activity.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Anti-Infective Agents / chemistry
-
Anti-Infective Agents / isolation & purification*
-
Anti-Infective Agents / pharmacology*
-
Bacillus / chemistry*
-
Bacillus subtilis / drug effects
-
Escherichia coli / drug effects
-
Ethers, Cyclic / chemistry
-
Ethers, Cyclic / isolation & purification*
-
Ethers, Cyclic / pharmacology*
-
Marine Biology
-
Microbial Sensitivity Tests
-
Molecular Structure
-
Saccharomyces cerevisiae / drug effects
Substances
-
Anti-Infective Agents
-
Ethers, Cyclic
-
macrolactin 1
-
macrolactin 2
-
macrolactin 3