Menelloides C and D, new sesquiterpenoids from the Gorgonian coral Menella sp

Shih-Yao Kao; Jui-Hsin Su; Tsong-Long Hwang; Jyh-Horng Sheu; Zhi-Hong Wen; Yang-Chang Wu; Ping-Jyun Sung

doi:10.3390/md9091534

Menelloides C and D, new sesquiterpenoids from the Gorgonian coral Menella sp

Mar Drugs. 2011;9(9):1534-1542. doi: 10.3390/md9091534. Epub 2011 Sep 14.

Authors

Shih-Yao Kao^{1

2}, Jui-Hsin Su^{1

2

3}, Tsong-Long Hwang⁴, Jyh-Horng Sheu^{3

5}, Zhi-Hong Wen^{3

5}, Yang-Chang Wu^{6

7}, Ping-Jyun Sung^{1

2

3

5

8}

Affiliations

¹ Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan.
² National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan.
³ Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
⁴ Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan.
⁵ Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
⁶ Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung 404, Taiwan.
⁷ Natural Medicinal Products Research Center and Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan.
⁸ Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 974, Taiwan.

Abstract

Two new metabolites, including a lindenane-type sesquiterpenoid, menelloide C (1), and a germacrane-type sesquiterpenoid, menelloide D (2), were isolated from a Formosan gorgonian coral identified as Menella sp. The structures of 1 and 2 were established by spectroscopic methods and 2 displayed a weak inhibitory effect on the release of elastase by human neutrophils.

Keywords: Menella; elastase; germacrane; lindenane; menelloide; sesquiterpenoid.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anthozoa / metabolism*
Humans
Magnetic Resonance Spectroscopy
Pancreatic Elastase / antagonists & inhibitors
Sesquiterpenes / chemistry
Sesquiterpenes / isolation & purification*
Sesquiterpenes / pharmacology

Substances

Sesquiterpenes
menelloide C
menelloide D
Pancreatic Elastase