Two new terpenoids from endophytic fungus Periconia sp. F-31

Chem Pharm Bull (Tokyo). 2011;59(12):1541-4. doi: 10.1248/cpb.59.1541.

Abstract

Two new terpenoids, (+)-(3S,6S,7R,8S)-periconone A (1) and (-)-(1R,4R,6S,7S)-2-caren-4,8-olide (2), have been isolated from an endophytic fungus Periconia sp., which was collected from the plant Annona muricata. Their structures were elucidated on the basis of extensive spectroscopic analyses. In the in vitro assays, the two compounds showed low cytotoxic activities against six human tumor cell lines (HCT-8, Bel-7402, BGC-823, A549, A2780 and MCF-7) with IC(50)>10(-5) M.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Annona / microbiology*
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / isolation & purification
  • Antineoplastic Agents / pharmacology*
  • Ascomycota / chemistry*
  • Cell Line, Tumor
  • Diterpenes / chemistry
  • Diterpenes / isolation & purification
  • Diterpenes / pharmacology
  • Drug Screening Assays, Antitumor
  • Humans
  • Models, Molecular
  • Neoplasms / drug therapy
  • Spectrum Analysis
  • Terpenes / chemistry*
  • Terpenes / isolation & purification
  • Terpenes / pharmacology*

Substances

  • Antineoplastic Agents
  • Diterpenes
  • Terpenes
  • periconicin A