Bio-composite scaffolds containing chitosan/nano-hydroxyapatite/nano-copper-zinc for bone tissue engineering

Int J Biol Macromol. 2012 Jan 1;50(1):294-9. doi: 10.1016/j.ijbiomac.2011.11.013. Epub 2011 Nov 23.

Abstract

The current study involves fabrication and characterization of bio-composite scaffolds containing chitosan (CS), nano-hydroxyapatite (nHAp) and Cu-Zn alloy nanoparticles (nCu-Zn) by freeze drying technique. The fabricated composite scaffolds (CS/nHAp and CS/nHAp/nCu-Zn) were characterized by SEM, EDX, XRD and FT-IR studies. The addition of nCu-Zn in the CS/nHAp scaffolds significantly increased swelling, decreased degradation, increased protein adsorption, and increased antibacterial activity. The CS/nHAp/nCu-Zn scaffolds had no toxicity towards rat osteoprogenitor cells. So the developed CS/nHAp/nCu-Zn scaffolds have advantageous and potential applications over the CS-nHAp scaffolds for bone tissue engineering.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adsorption
  • Animals
  • Animals, Newborn
  • Anti-Bacterial Agents / chemistry
  • Bone Regeneration
  • Bone and Bones / metabolism
  • Chitosan / chemistry*
  • Copper / chemistry
  • Durapatite / chemistry*
  • Escherichia coli / metabolism
  • Microscopy, Electron, Scanning / methods
  • Nanoparticles / chemistry
  • Nanotechnology / methods
  • Rats
  • Rats, Wistar
  • Spectroscopy, Fourier Transform Infrared / methods
  • Staphylococcus aureus / metabolism
  • Stem Cells / cytology
  • Tissue Engineering / methods*
  • Tissue Scaffolds / chemistry
  • X-Ray Diffraction / methods
  • Zinc / chemistry

Substances

  • Anti-Bacterial Agents
  • Copper
  • Chitosan
  • Durapatite
  • Zinc