Effects of exogenous carbon monoxide on radiation-induced bystander effect in zebrafish embryos in vivo

V W Y Choi; M Y P Wong; S H Cheng; K N Yu

doi:10.1016/j.apradiso.2011.11.018

Effects of exogenous carbon monoxide on radiation-induced bystander effect in zebrafish embryos in vivo

Appl Radiat Isot. 2012 Jul;70(7):1075-9. doi: 10.1016/j.apradiso.2011.11.018. Epub 2011 Nov 18.

Authors

V W Y Choi¹, M Y P Wong, S H Cheng, K N Yu

Affiliation

¹ Department of Physics and Materials Science, City University of Hong Kong, Tat Chee Avenue, Kowloon Tong, Hong Kong.

PMID: 22119559
DOI: 10.1016/j.apradiso.2011.11.018

Abstract

In the present work, the influence of a low concentration of exogenous carbon monoxide (CO) liberated from tricarbonylchloro(glycinato)ruthenium (II) (CORM-3) on the radiation induced bystander effect (RIBE) in vivo between embryos of the zebrafish was studied. RIBE was assessed through the number of apoptotic signals revealed on embryos at 25 h post fertilization (hpf). A significant attenuation of apoptosis on the bystander embryos induced by RIBE in a CO concentration dependent manner was observed.

MeSH terms

Animals
Apoptosis / drug effects
Apoptosis / radiation effects
Bystander Effect / drug effects*
Carbon Monoxide / pharmacology*
Embryo, Nonmammalian / drug effects*
Embryo, Nonmammalian / radiation effects
Zebrafish / embryology*

Substances

Carbon Monoxide