Sorbicins A and B, new urease and serine protease inhibitory triterpenes from Sorbus cashmiriana

J Asian Nat Prod Res. 2011 Dec;13(12):1081-6. doi: 10.1080/10286020.2011.626405.

Abstract

Two new lupene-type triterpenes, sorbicins A and B, have been isolated from the chloroform-soluble fraction of the MeOH extract from the whole plant of Sorbus cashmiriana, and their structures were elucidated by spectroscopic techniques including 2D NMR. Both compounds displayed urease and α-chymotrypsin inhibitory potential.

MeSH terms

  • Chymotrypsin / antagonists & inhibitors
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Pakistan
  • Serine Proteinase Inhibitors / chemistry
  • Serine Proteinase Inhibitors / isolation & purification*
  • Serine Proteinase Inhibitors / pharmacology*
  • Sorbus / chemistry*
  • Triterpenes / chemistry
  • Triterpenes / isolation & purification*
  • Triterpenes / pharmacology*
  • Urease / antagonists & inhibitors*

Substances

  • Serine Proteinase Inhibitors
  • Triterpenes
  • sorbicin A
  • sorbicin B
  • Chymotrypsin
  • alpha-chymotrypsin
  • Urease