Abstract
Two closely related Enterobacter aerogenes isolates presented a new identical aac(6')-Ib-cr genetic environment, including IS26. One isolate showed lower MICs of ciprofloxacin, norfloxacin, tobramycin, and amikacin and decreased expression of aac(6')-Ib-cr, which might be related to a 12-bp deletion causing a displacement of the -10 box upstream of the aac(6')-Ib-cr gene.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetyltransferases / genetics
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Acetyltransferases / metabolism*
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Anti-Bacterial Agents / pharmacology*
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Base Sequence
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Ciprofloxacin / pharmacology*
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Drug Resistance, Bacterial / genetics*
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Enterobacter aerogenes / drug effects*
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Enterobacter aerogenes / enzymology
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Enterobacter aerogenes / genetics
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Enterobacter aerogenes / isolation & purification
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Enterobacteriaceae Infections / microbiology
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Gene Deletion
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Gene Expression Regulation, Bacterial*
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Humans
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Microbial Sensitivity Tests
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Molecular Sequence Data
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Sequence Analysis, DNA
Substances
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Anti-Bacterial Agents
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Ciprofloxacin
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Acetyltransferases
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aminoglycoside N(6')-acetyltransferase
Associated data
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GENBANK/JF718780
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GENBANK/JF718781
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GENBANK/JF729199