Changes in ciprofloxacin resistance levels in Enterobacter aerogenes isolates associated with variable expression of the aac(6')-Ib-cr gene

Antimicrob Agents Chemother. 2012 Feb;56(2):1097-100. doi: 10.1128/AAC.05074-11. Epub 2011 Nov 21.

Abstract

Two closely related Enterobacter aerogenes isolates presented a new identical aac(6')-Ib-cr genetic environment, including IS26. One isolate showed lower MICs of ciprofloxacin, norfloxacin, tobramycin, and amikacin and decreased expression of aac(6')-Ib-cr, which might be related to a 12-bp deletion causing a displacement of the -10 box upstream of the aac(6')-Ib-cr gene.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetyltransferases / genetics
  • Acetyltransferases / metabolism*
  • Anti-Bacterial Agents / pharmacology*
  • Base Sequence
  • Ciprofloxacin / pharmacology*
  • Drug Resistance, Bacterial / genetics*
  • Enterobacter aerogenes / drug effects*
  • Enterobacter aerogenes / enzymology
  • Enterobacter aerogenes / genetics
  • Enterobacter aerogenes / isolation & purification
  • Enterobacteriaceae Infections / microbiology
  • Gene Deletion
  • Gene Expression Regulation, Bacterial*
  • Humans
  • Microbial Sensitivity Tests
  • Molecular Sequence Data
  • Sequence Analysis, DNA

Substances

  • Anti-Bacterial Agents
  • Ciprofloxacin
  • Acetyltransferases
  • aminoglycoside N(6')-acetyltransferase

Associated data

  • GENBANK/JF718780
  • GENBANK/JF718781
  • GENBANK/JF729199