Abstract
NFY-C, a subunit of the transcription factor NFY, binds to the promoters of several eukaryotic genes, including cell cycle-related genes. RORA is a steroid hormone receptor implicated in a range of important cellular processes. We evaluated the expression of NFY-C and RORA in colorectal adenocarcinomas and normal colonic tissue. NFY-C expression was elevated in adenocarcinomas. Moreover, NFY-C mRNA levels correlated with time to disease progression, while NFY-C protein expression was significantly higher in metastatic disease. RORA expression was downregulated in CRC adenocarcinomas compared to normal controls and correlated with time to disease progression. The role of NFY-C and RORA in CRC merits further investigation.
Copyright © 2011 Elsevier GmbH. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenocarcinoma / genetics*
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Adenocarcinoma / metabolism
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Adenocarcinoma / pathology
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Aged
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CCAAT-Binding Factor / analysis
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CCAAT-Binding Factor / genetics*
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Colorectal Neoplasms / genetics*
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Colorectal Neoplasms / metabolism
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Colorectal Neoplasms / pathology
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Disease Progression
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Female
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Gene Expression Profiling
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Gene Expression Regulation, Neoplastic*
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Humans
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Immunohistochemistry
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Male
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Neoplasm Staging
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Nuclear Receptor Subfamily 1, Group F, Member 1 / analysis
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Nuclear Receptor Subfamily 1, Group F, Member 1 / genetics*
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RNA, Messenger / analysis
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RNA, Messenger / genetics
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Real-Time Polymerase Chain Reaction
Substances
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CCAAT-Binding Factor
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NFYC protein, human
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Nuclear Receptor Subfamily 1, Group F, Member 1
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RNA, Messenger
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RORA protein, human