Altered expression of NFY-C and RORA in colorectal adenocarcinomas

Acta Histochem. 2012 Oct;114(6):553-61. doi: 10.1016/j.acthis.2011.10.005. Epub 2011 Nov 21.

Abstract

NFY-C, a subunit of the transcription factor NFY, binds to the promoters of several eukaryotic genes, including cell cycle-related genes. RORA is a steroid hormone receptor implicated in a range of important cellular processes. We evaluated the expression of NFY-C and RORA in colorectal adenocarcinomas and normal colonic tissue. NFY-C expression was elevated in adenocarcinomas. Moreover, NFY-C mRNA levels correlated with time to disease progression, while NFY-C protein expression was significantly higher in metastatic disease. RORA expression was downregulated in CRC adenocarcinomas compared to normal controls and correlated with time to disease progression. The role of NFY-C and RORA in CRC merits further investigation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / genetics*
  • Adenocarcinoma / metabolism
  • Adenocarcinoma / pathology
  • Aged
  • CCAAT-Binding Factor / analysis
  • CCAAT-Binding Factor / genetics*
  • Colorectal Neoplasms / genetics*
  • Colorectal Neoplasms / metabolism
  • Colorectal Neoplasms / pathology
  • Disease Progression
  • Female
  • Gene Expression Profiling
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Immunohistochemistry
  • Male
  • Neoplasm Staging
  • Nuclear Receptor Subfamily 1, Group F, Member 1 / analysis
  • Nuclear Receptor Subfamily 1, Group F, Member 1 / genetics*
  • RNA, Messenger / analysis
  • RNA, Messenger / genetics
  • Real-Time Polymerase Chain Reaction

Substances

  • CCAAT-Binding Factor
  • NFYC protein, human
  • Nuclear Receptor Subfamily 1, Group F, Member 1
  • RNA, Messenger
  • RORA protein, human